![]() Other neurotransmitters implicated include norepinephrine, dopamine, glutamate, and brain-derived neurotrophic factor.Clinical and preclinical trials suggest a disturbance in central nervous system serotonin (5-HT) activity as an important factor.Current evidence points to a complex interaction between neurotransmitter availability and receptor regulation and sensitivity underlying the affective symptoms.The underlying pathophysiology of major depressive disorder has not been clearly defined. ![]()
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